Delta Plus Variant of Covid causing havoc

It is the job of viruses to keep mutating, as natural selection forces them into it. So it is with the novel coronavirus too.

Delta Plus Variant of Covid causing havoc

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• The story: It is the job of viruses to keep mutating, as natural selection forces them into it. So it is with the novel coronavirus too. As new variants kept emerging, India's Union Ministry of Health and Family Welfare (MoHFW) warned people against the new Covid-19 strain ‘Delta Plus’ (DP).
• Points to note: The Delta plus (B.1.617.2.1/(AY.1) was a new variant of the SARS-CoV-2 coronavirus formed due to a mutation in the Delta strain of the virus (B.1.617.2 variant). It is technically the next generation of SARS-COV-2. This mutant was first detected in Europe in March 2021.

1. The Delta variant that was first detected in India (in February 2021) eventually became a huge problem for the whole world. However, the Delta Plus variant, at present, is limited to smaller areas in the country.
2. It is resistant to monoclonal antibodies cocktail. Since it’s a new variant, its severity is still unknown.
3. People reported symptoms like headaches, sore throats, runny noses, and fever.
4. The World Health Organisation (WHO) is tracking this variant as part of the Delta variant, it is doing so for other Variants of Concern with additional mutations.

• Transmissibility: It acquired the spike protein mutation called K417N which is also found in the Beta variant first identified in South Africa. The spike protein is used by SARS-CoV-2, the virus which causes Covid-19, to enter the host cells. Some scientists fear that the mutation combined with other existing features of the Delta variant could make it more transmissible.
• Worries: Multiple studies are ongoing in India and globally to test the effectiveness of vaccines against the Delta plus Covid-19 mutation. India's health ministry warned that regions where it has been found "may need to enhance their public health response by focusing on surveillance, enhanced testing, quick contact-tracing, and priority vaccination." There are worries Delta Plus would inflict another wave of infections on India after it emerged from the world’s worst surge in cases only recently. Just over 4% of Indians are fully vaccinated and about 18% have received one dose so far.
• Virus variants: Variants of a virus have one or more mutations that differentiate it from the other variants that are in circulation. While most mutations are useless or harmful for the virus itself, some make it easier for the virus to survive. The SARS-CoV-2 (Corona) virus is evolving fast because of the scale at which it has infected people around the world. High levels of circulation mean it is easier for the virus to change as it is able to replicate faster. The original pandemic virus (founder variant) was Wu.Hu.1 (Wuhan virus). In a few months, variant D614G emerged and became globally dominant. Indian SARS-CoV-2 Consortium on Genomics (INSACOG) is a multi-laboratory, multi-agency, pan-India network to monitor genomic variations in the SARS-CoV-2.
• Summary: The Global Initiative on Sharing All Influenza Data (GISAID) is a public platform started by the World Health Organization (WHO) in 2008 for countries to share genome sequences. The GISAID Initiative promotes the international sharing of all influenza virus sequences, related clinical and epidemiological data associated with human viruses, and geographical as well as species-specific data associated with avian and other animal viruses.

 

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